January 01, 2016. The scientists involved in the PELICO Project began the research into cytotoxic photosensitive compounds, analogues of the known antibiotic sramicidin S (Angewandte Chemie, DOI: 10.1002/anie.201600506).
December 09, 2016. Senior Latvian Institute of Organic Synthesis leaders and PELICO Project coordinator visited Enamine and Ukrorgsyntez. They met with the colleagues from Ukraine and discussed prospects of further cooperation as well as current results on the Project. On the photo below, from left to right: Chairman of the Scientific Board of the Latvian Institute of Organic Synthesis Prof. Ivars Kalvins; Director of Ukrorgsyntez Dr. Sergii Dovgopolyi; PELICO Project coordinator at Latvian Institute of Organic Synthesis Prof. Aigars Jirgensons; Director of Latvian Institute of Organic Synthesis Prof. Osvalds Pugovics. In an informal meeting with Enamine scientists, the guests from Riga shared insightful experience in drug design. In particular, Prof. Ivars Kalvins, the inventor of anti-ischemic drug Mildronate, new Mildronate-containing pharmaceutical products (Capicor, MildronateGX, Neomildronate), immunostimulator Leakadine and anti-cancer drug Belinostat spoke of exciting stories about drug development in Latvia.
December 27, 2016. Research pharmacokinetic and toxicity studies of the photoswitchable gramicidin S analogues on mice was finished at Bienta for Enamine under the PELICO Project. Valuable experience on working with photosensitive drugs, their laser activation in tissue (see the photo below) and subsequent analysis of samples was acquired. The studies confirmed the preliminary data published earlier by us in Angewandte Chemie (DOI: 10.1002/anie.201600506) and found new results which are very encouraging for the use of the peptidomimetics in photodynamic therapy of cancer.
June 16, 2017. PELICO Project mid-term meeting is organized by Enamine Ltd. in Kyiv, Ukraine. The meeting agenda can be downloaded here.
June 17, 2017. Workshop «Bioactive Peptides and their Photocontrol», Venue: RUS Hotel, 4 Hospitalna str., Kyiv 01601, Ukraine.
The workshop is organized under the current H2020 PELICO Project by its coordinator, Enamine Ltd. The aim of the workshop is to promote dissemination of the results obtained under the project, exchanging the ideas relevant to peptide-based drug design, and specifically to photopharmacology by photosensitive peptidomimetics. It is anticipated that invited senior and experienced scientists, the experts in the field of chemistry, biochemistry, pharmacology, will inspire young talents working under the project. The workshop program is available for download.