EVENTS & ACTIVITIES

January 01, 2016. The scientists involved in the PELICO Project began the research into cytotoxic photosensitive compounds, analogues of the known antibiotic sramicidin S (Angewandte Chemie, DOI: 10.1002/anie.201600506).

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December 09, 2016. Senior Latvian Institute of Organic Synthesis leaders and PELICO Project coordinator visited Enamine and Ukrorgsyntez. They met with the colleagues from Ukraine and discussed prospects of further cooperation as well as current results on the Project. On the photo below, from left to right: Chairman of the Scientific Board of the Latvian Institute of Organic Synthesis Prof. Ivars Kalvins; Director of Ukrorgsyntez Dr. Sergii Dovgopolyi; PELICO Project coordinator at Latvian Institute of Organic Synthesis Prof. Aigars Jirgensons; Director of Latvian Institute of Organic Synthesis Prof. Osvalds Pugovics. In an informal meeting with Enamine scientists, the guests from Riga shared insightful experience in drug design. In particular, Prof. Ivars Kalvins, the inventor of anti-ischemic drug Mildronate, new Mildronate-containing pharmaceutical products (Capicor, MildronateGX, Neomildronate), immunostimulator Leakadine and anti-cancer drug Belinostat spoke of exciting stories about drug development in Latvia.

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December 27, 2016. Research pharmacokinetic and toxicity studies of the photoswitchable gramicidin S analogues on mice was finished at Bienta for Enamine under the PELICO Project. Valuable experience on working with photosensitive drugs, their laser activation in tissue (see the photo below) and subsequent analysis of samples was acquired. The studies confirmed the preliminary data published earlier by us in Angewandte Chemie (DOI: 10.1002/anie.201600506) and found new results which are very encouraging for the use of the peptidomimetics in photodynamic therapy of cancer.

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June 16, 2017. PELICO Project mid-term meeting was organized by Enamine Ltd. in Kyiv, Ukraine. The meeting agenda can be downloaded here. Project officer Eleftheria Lykouressi and the expert Dr. Julia Maria Alvarez Gutierrez attended the meeting. The coordinator, WP leaders and secondees presented their contribution to the Project and the progress made during the first year of the implementation.

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June 17, 2017. Workshop «Bioactive Peptides and their Photocontrol», Venue: RUS Hotel, 4 Hospitalna str., Kyiv 01601, Ukraine.

The workshop was organized by the coordinator, Enamine Ltd. The aim of the workshop was to promote dissemination of the results obtained under the project, exchanging the ideas relevant to peptide-based drug design, and specifically to photopharmacology by photosensitive peptidomimetics. Senior and experienced scientists, the experts in the field of chemistry, biochemistry, pharmacology, attended the event and inspired young talents working under the project. The participants visited Enamine facilities.

The workshop program is available for download.

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November 28, 2017. Prof. Igor V. Komarov participated in the conference «Unlocking the EU Research and Innovation Potential through Excellence in Cooperation» organised by Lithuanian RDI Liaison Office (LINO) and Ukrainian Think Tanks Liaison Office in Brussels. The main aim of this event was to increase the visibility of the Research and Innovation potential through the analysis of Lithuania’s and Ukraine’s examples. Igor V. Komarov represented Enamine Ltd. and the current PELICO Project. The agenda of the event can be downloaded here.

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SECONDMENTS

SCIENTIST FROM TO MAIN TASK OF SECONDMENT,WP DATES/STATUS
Oleksandr Ishchenko (ESR)

secondments_1

consortium_1  ⇒  consortium_4 Synthesis of diarylethene-derived photoswitchable building blocks to be incorporated in peptides, WP1 01.02.2016-30.04.2016
Completed
Hanna Zhdanova (ESR)

secondments_2

consortium_4  ⇒   consortium_1 In vitro testing the cytotoxic activity of the photoswitchable gramicidin S analogues, WP1 13.03.2016-17.04.2016
Completed
Oleksandr Borysov (ER)

secondments_3

consortium_3  ⇒  consortium_1 Synthesis of spirocyclic photoswitchable building blocks to be incorporated in peptides, WP4 11.01.2016-13.06.2016
Completed
Prof. Igor V. Komarov (ER)

consortium_9

consortium_1  ⇒  consortium_4 arranging the following studies and preparing/testing equipment at KIT W1 23.01.2016-25.02.2016

30.04.2016-15.05.2016

02.07.2016-16.07.2016

04.07.2017-23.07.2017

02.08.2017-19.08.2017
Pending

Olexandr Stryzhak (ER)

secondments_4

consortium_1  ⇒  consortium_2 Synthesis of  diarylethene-based photoswitchable “stapled” peptides, WP3 31.05.2016-31.05.2017
Completed
Oleg Babii (ER)

secondments_5

consortium_1  ⇒  consortium_4 Synthesis of novel diarylethene-based photoswitchable peptidomimetics (lead optimisation)

WP2

01.04.2016-31.01.2017

Completed

Vitalii Polovynko (ER)

PolovynkoII

consortium_1  ⇒  consortium_3 NMR study of the photocontrollable peptidomimetic structure in membrane-mimicking environment

WP4

30.05.2016-30.08.2016

Completed

Hanna Zhdanova (ESR)

secondments_2

consortium_4 ⇒  consortium_1  In vitro testing the cytotoxic activity of the photoswitchable gramicidin S analogues, WP1 16.08.2016-16.10.2016

Completed

Oleksandr Ishchenko (ESR)

secondments_1

 consortium_1  ⇒  consortium_4  Synthesis of novel photoswitchable gramicidin S analogues (lead optimisation), WP2 11.02.2017-14.11.2017

Completed

Gundars Leitis (ER)

Gundars_Leitis

consortium_3  ⇒  consortium_1 Synthesis of spirocyclic photoswitchable building blocks and their incorporation into peptides, WP4 31.10.2016-31.01.2017

Completed